Dubin Johnson syndrome

The Dubin Johnson syndrome - An inherited disorder that is caused by an autosomal recessive genetic trait (see genetic disorders). Dubin–Johnson syndrome is characterized by long-standing, mild jaundice (yellowing of the skin and the whites of the eyes), which may not become apparent until puberty or adulthood.

There is an abnormality in the transportation of bilirubin (the main pigment found in bile) from the liver to the biliary system, which causes the bilirubin to accumulate in the liver.

No specific treatment is available. Affected people are advised to avoid drinking alcohol, and to avoid taking a range of medications that are processed by the liver, for example oral contraceptives. Genetic counselling may be offered to prospective parents who have a family history of Dubin–Johnson syndrome.