Many factors affect drug metabolism, including personal attributes, such as body weight, age, and sex, physiologic factors, such as state of health or disease processes, acid-base and fluid and electrolyte balance; permeability; diurnal rhythm; and circulatory capability.
Genetic and immunologic factors play a role in drug metabolism, as do psychologic, emotional and environmental influences, drug tolerance, and cumulation of drugs. Responses to drugs vary, depending on the speed with which the drug is absorbed into the blood or tissues and the effectiveness of the body’s circulatory system.
3/1/14
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