Vecuronium - a non-depolarising neuromuscular blocker with minimal cardiovascular effects. It is metabolised in the liver to inactive products and has a duration of action of 20–30 min. Dose may have to be reduced in hepatic/ renal failure.
Uses
Muscle paralysis
Contraindications
Airway obstruction
To facilitate tracheal intubation in patients at risk of regurgitation
Administration
• Initial dose: 100 μg/kg IV
• Incremental dose: 20–30 μg/kg according to response
Monitor with peripheral nerve stimulator
How not to use vecuronium
As part of a rapid sequence induction
In the conscious patient
By persons not trained to intubate the trachea
Cautions
Breathing circuit (disconnection)
Prolonged use (disuse muscle atrophy)
Organ failure
Hepatic: prolonged duration of action
Renal: prolonged duration of action
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