Ticarcillin + Clavulanic Acid (Timentin)

Timentin is a broad-spectrum antibiotic with bactericidal activity against a wide range of Gram + ve and Gram -ve aerobic and anaerobic bacteria. It contains ticarcillin and clavulanic acid.The presence of clavulanic acid extends the spectrum of activity of ticarcillin to include many β-lactamase-producing bacteria normally resistant to ticarcillin and other β-lactam antibiotics. Timentin acts synergistically with aminoglycosides against a number of organisms, including Pseudomonas.

Timentin is not active against MRSA.

Uses
Intra-abdominal infections including peritonitis
Pneumonia
Urinary tract infections
Skin and soft tissue infections

Contraindications
Hypersensitivity to β-lactam antibiotics (penicillins and cephalosporins)

Administration
• IV infusion: 3.2 g 6–8 hourly (maximum 3.2 g 4 hourly)
Reconstitute 3.2-g vial with 100 ml WFI or glucose 5%, given over 30 min

In renal impairment:

CC (ml/min)	Dose (g)	Interval (h)
<30	3.2	8
10–30	1.6	8
>10	1.6	12

How not use Timentin

Do not give IV infusion over longer than 40 min, as this may result in subtherapeutic concentrations

Adverse effects

Hypersensitivity

Hypokalaemia

False-positive Coombs’ test

Thrombocytopenia

Prolonged prothrombin time

Cautions

Renal impairment (reduce dose)

Each 3.2-g vial of Timentin contains 15.9 mmol of sodium. A typical

daily dose regime may contain over 60 mmol Na+

Renal replacement therapy

CVVH unknown dialysability, dose at 2.4 g every 6–8 hours. HD dialysed, dose 1.6 g every 12 hours. PD not dialysed, dose 1.6 g 12 hourly