Ranitidine

Ranitidine - It is a specific histamine H2-antagonist that inhibits basal and stimulated secretion of gastric acid, reducing both the volume and the pH of the secretion.

Uses
Peptic ulcer disease
Prophylaxis of stress ulceration
Premedication in patients at risk of acid aspiration

Administration
• IV bolus: 50 mg 8 hourly
Dilute to 20 ml with sodium chloride 0.9% or glucose 5% and give over 5 min
• Oral 150 mg 12 hourly
For prevention of NSAID-induced GI toxicity, double the doses stated above

In renal impairment:

CC (ml/min)	Percentage of normal dose
< 10	50–100

How not to use ranitidine

Do not give rapidly as IV bolus (bradycardia, arrhythmias)

Adverse effects

Hypersensitivity reactions

Bradycardia

Transient and reversible worsening of liver function tests

Reversible leukopenia and thrombocytopenia

Organ failure

Renal: reduce dose

Hepatic: reduce dose (increased risk of confusion)

Renal replacement therapy

No further dose modification is required during renal replacement therapy