Prochlorperazine

Prochlorperazine - a phenothiazine that inhibits the medullary chemoreceptor trigger zone.

Uses
Nausea and vomiting

Contraindications
Parkinson’s disease

Administration
• IM/IV: 12.5 mg 6 hourly The IV route is not licensed
• PO/NG: acute attack – 20 mg then 10 mg after 2 hours; maintenance dose 5–10 mg 8–12 hourly

Adverse effects
Drowsiness
Postural hypotension, tachycardia
Extrapyramidal movements particularly in children,elderly and debilitated

Cautions
Concurrent use of other CNS depressants (enhanced sedation)

Organ failure
CNS: sedative effects increased
Hepatic: can precipitate coma
Renal: increase cerebral sensitivity

Renal replacement therapy
No further dose modification is required during renal replacement therapy