Neostigmine - is a cholinesterase inhibitor leading to prolongation of Ach action.This will enhance parasympathetic activity in the gut and increase intestinal motility. When used for acute colonic pseudo-obstruction, organic obstruction of the gut must first be excluded and it should not be used shortly after bowel anastomosis (Ponec RJ, et al. N Engl J Med 1999; 341: 137–41). Colonic pseudo-obstruction, which is the massive dilation of the colon in the absence of mechanical obstruction, can develop after surgery or severe illness. Most cases respond to conservative treatment. In patients who do not respond, colonic decompression is often performed to prevent ischaemia and perforation of the bowel. Colonoscopy in these patients is not always successful and can be accompanied by complications such as perforation.
Uses
Colonic pseudo-obstruction (unlicensed)
Administration
• IV bolus: 2.5 mg, repeated 3 hours later if no response to initial dose Monitor ECG (may need to give atropine or other anticholinergic
drugs to counteract symptomatic bradycardia)
Contraindications
Mechanical bowel obstruction
Urinary obstruction
How not to use neostigmine
It should not be used shortly after bowel anastomosis
Adverse effects
Increased sweating
Excess salivation
Nausea and vomiting
Abdominal cramp
Diarrhoea
Bradycardia
Hypotension
These muscarinic side-effects are antagonised by atropine
Cautions
Asthma
Organ failure
Renal: reduce dose
Renal replacement therapy
No further dose modification is required during renal replacement therapy
1 comments:
Hiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patient we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patient Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal treatment.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com . We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Doctor Itua Herbal Treatment..He assured me he can cure the following disease..Hiv,Cancer,Herpes Virus,Hpv,Pile,Weak Erection,Lyme Disease,Epilepsy,Glaucoma.,Brain Tumor,psoriasis, Cataracts,Macular degeneration,Cardiovascular disease,Chronic Diarrhea,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,
Dementia. ,Bladder Cancer,Autism,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Tay tach disease,Non Hodgkin Lymphoma,Skin Cancer,Lupus,Uterine Cancer,Prostate Cancer, Seizures, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Stroke,Hpv,Weak Erection,Liver/Kidney Inflammatory,Men/Woman infertility, bowel disease ,Huntington's disease ,Diabetes,Fibroid.
Post a Comment