Isoprenaline

Isoprenaline - is a B1- and B2-adrenoceptor agonist causing: ↑ HR,  ↑automaticity, ↑ contractility, ↓ diastolic BP, ↑ systolic BP, ↑ myocardial oxygen demand and bronchodilation. It has a half-life of <5min.

Uses
Complete heart block, while getting temporary pacing established

Contraindications
Tachyarrhythmias
Heart block caused by digoxin

Administration
• IV infusion: up to 20 μg/min
4 mg made up to 50 ml glucose 5% (80 μg/ml)

Dose (ug/min)	Infusion rate (ml/h)
1	0.75
2	1.5
4	3
10	7.5
20	15

How not to use isoprenaline
Do not use sodium chloride 0.9% as a diluent

Adverse effects
Tachycardia
Arrhythmias
Angina
Hypotension

Cautions
Risk of arrhythmias with concurrent use of other sympathomimetics and volatile anaesthetics