Uses
Haemofiltration (unlicensed), as an alternative to unfractionated heparin in heparin-induced thrombocytopenia or in addition to heparin if filter life is short
ARDS/Pulmonary hypertension (unlicensed)
Peripheral insufficiency
Administration
• Haemofiltration
Infusion into extracorporeal circuit 2–10 ng/kg/min, start 1 h before haemofiltration. For peripheral insufficiency, administer this dose IV. Available in vials containing 500 μg (500 000 nanograms) epoprostenol. Reconstitute the powder with 10 ml of the diluent provided. Once powder has dissolved, withdraw the contents from the vial and inject into the remaining diluents (40 ml) in the large vial.This results in a concentration of epoprostenol. Connect the filter provided to a needle and withdraw 50 ml of the solution into a 50-ml syringe.
Dosage chart (ml/h)
Weight
(kg)
|
Dose
(ng/kg/min)
|
||||||||||
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
|||
50
|
0.6
|
0.9
|
1.2
|
1.5
|
1.8
|
2.1
|
2.4
|
2.7
|
3.0
|
||
60
|
0.7
|
1.1
|
1.4
|
1.8
|
2.2
|
2.5
|
2.9
|
3.2
|
3.6
|
||
70
|
0.8
|
1.3
|
1.7
|
2.1
|
2.5
|
2.9
|
3.4
|
3.8
|
4.2
|
||
80
|
1.0
|
1.4
|
1.9
|
2.4
|
2.9
|
3.4
|
3.8
|
4.3
|
4.8
|
||
90
|
1.1
|
1.6
|
2.2
|
2.7
|
3.2
|
3.8
|
4.3
|
4.9
|
5.4
|
||
100
|
1.2
|
1.8
|
2.4
|
3.0
|
3.6
|
4.2
|
4.8
|
5.4
|
6.0
| ||
• ARDS/pulmonary hypertension
Nebulised (unlicensed): 1–20 ng/kg/min of the reconstituted powder (500 μg epoprostenol reconstituted with the 50 ml diluent provided) into ventilator circuit via compressed air nebuliser systems.
How not to use epoprostenol
To avoid systemic side-effects in CVVH, it may be preferable to administer epoprostenol into the extracorporeal circuit and not into the patient.
Adverse effects
Flushing
Headaches
Hypotension
Bradycardia
Cautions
Epoprostenol may potentiate heparin effects
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