1/10/14

Types of Insulin

Types of Insulin

Agent
Onset
Peak
Duration
Rapid-acting
insulins
insulin lispro (Humalog)
5 min
60–90 min
4–6 hours
insulin aspart (NovoLog)
10–20 min
1–3 hours
3–5 hours
Short-acting
insulins
concentrated insulin: Iletin II regular (concentrated) Insulin U-500.
Caution: Do not administer IV because of the potential for overdosage.
30–60 min
2–3 hour
5–7 hours
regular insulin: (Humulin R, Insulin-Toronto, Novolin R, Iletin II Regular,
Velosulin BR)
Caution: Regular insulin is the only insulin that can be administered IV.
SC route:
30–60 min

IV route:
10–30 min
SC route:
2–4 hours

IV route:
15–30 min
SC route:
5–7 hours

IV route:
30–60 min
Intermediateacting
insulins
isophane (NPH): (Humulin N, NPH
Iletin II, Novolin Ge NPH, Novolin N)
1–2 hours
8–12 hours
18–24 hours
lente: (Humulin L, Novolin Ge Lente, Novolin L)

No longer manufactured as of July, 2005
1–2 hours
8–12 hours
18–24 hours
Long-acting
insulins
insulin glargine (Lantus)
Caution: Lantus insulin cannot be mixed
with other insulins; may cause
unpredictable results.
Onset: 1 hour. Provides a constant
concentration over a 24-hour period
with no pronounced peak.
Onset: 1 hour. Provides a constant
concentration over a 24-hour period
with no pronounced peak.
Onset: 1 hour. Provides a constant
concentration over a 24-hour period
with no pronounced peak.
insulin detemir (Levemir
2–4 hours
None
24 hours
ultralente: (Humulin U, Novolin U)
No longer manufactured
4–8 hours
16–18 hours
36 hours
Pre-mixed
insulins
(Note: other
mixes are
available)
NPH/regular: (Humulin 50/50, Humulin
70/30, Novolin 70/30)
30–60 min
2–8 hours
24 hours
aspart protamine/aspart (NovoLog Mix
70/30)
10–20 mi
2 1/2 hours
24 hours
lispro protamine/lispro (Humalog Mix
75/25)
5 min
2 hours
22 hours

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