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1/4/14

Pharmacokinetics in the Elderly

Pharmacokinetics - is the way that the body absorbs, distributes, metabolizes, and excretes medication. Age-related physiological changes affect body systems, altering pharmacokinetics and increasing or altering a drug’s effect.


Physiological Change
Effect on Pharmacokinetics
Absorption
Decreased intestinal motility
Diminished blood flow to the gut
Delayed peak effect
Delayed signs and
symptoms of toxicity
Distribution
fluid volume
body fat
percentage
plasma proteins
lean body mass
serum concentration
of water-soluble drugs
half-life of fat-soluble
drugs
amount of active drug
drug concentration
Metabolism
blood flow to liver
liver function
rate of drug clearance
by the liver
accumulation of some
drugs
Excretion
kidney function
creatinine
clearance
accumulation of drugs
that are normally
excreted by the kidneys


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