Local Anaesthetics - These membrane-stabilizing drugs act by causing a reversible block to conduction along nerve fibres. The smaller nerve fibres are more sensitive, so that a differential block can occur where the small fibres carrying pain and autonomic impulses are blocked, sparing coarse touch and movement9 1 . Following most regional anaesthetic procedures, maximum arterial plasma concentrations of local anaesthetic develop within about 10-25 minutes9 1 . This has implications for outpatient practice if significant volumes of the drug are injected.
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